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Due to the risk of respiratory depression with concomitant use of skeletal muscle relaxants and opioids, consider prescribing an opioid overdose reversal agent [see WARNINGS, DOSAGE AND ADMINISTRATION]

doi: 10.1210/jc.2012-3855 136 SohnM

These components produce the tear films three layers: lipid, aqueous, and mucin, which are crucial for ocular lubrication and protection (The definition, 2007