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33,34 Bone-derived signals, such as osteocalcin (a non-collagenous protein secreted by osteoblasts) and sclerostin (a glycoprotein produced by osteocytes), maintain a bidirectional dialogue with energy metabolism and may influence systemic homeostasis, producing trans-systemic effects during growth

e-Pub 1981

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Holz, who closely follows the weight-loss drug race in his role as a health-care strategist for an investment firm, said he hopes to switch to an oral option from the injectable drug hes taking weekly now, if one becomes available, to maintain his weight loss