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Long-term Use and Zinc: Some studies suggest that long-term, high-dose glutathione supplementation may affect zinc levels

A recent study further demonstrated that proline catabolism via PRODH supports 3D growth of breast cancer cells, with elevated PRODH expression and proline oxidation in metastatic lesions compared with primary tumors, thereby promoting metastatic colonization and identifying PRODH as a potential target for metastasis suppression 64

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