Fusion constructs between glutaredoxins or peroxidases and roGFP2 yield specific redox sensors for monitoring spatiotemporal changes of intracellular glutathione or peroxide concentrations 32,61,62,69,72,73,74
3.2.5 Extracellular vesicles and exosomes Mesenchymal stem cells (MSCs) have been investigated for their role in organ protection in sepsis and acute respiratory distress syndrome (ARDS), primarily due to their ability to secrete beneficial exosomes that can transfer mitochondria or mitochondrial components to other cells (142)
69 Therefore, these NAD + -dependent enzymes, namely, sirtuins, PARPs, and cADPRSs, are able to coregulate each other in competition for the same intracellular limiting NAD + pool
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