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"In order to prevent the patent from lapsing, the amount listed above, which includes the required maintenance fee and the late payment fee, must be paid within the one-year period of grace following the filing date anniversary," a letter from regulators said, putting the anniversary date at March 20, 2019

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It argues that combination is what actually protects a patient, because it means someone reviews the health history, screens for contraindications, and tracks outcomes over time