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Description

Activated SIRT1 deacetylates PGC-1 resulting in increased transcriptional activity and thus, enhanced mitochondrial biogenesis Therapeutic Intervention for Hyperglycemia Many, if not all, of the vascular consequences of insulin resistance are due to the persistent hyperglycemia seen in type 2 diabetes

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The developed models can be divided into several main types: transwell systems (Helms et al., 2016

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