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The supply of CH 3 moieties depends on de novo synthesis from S-adenosylmethionine (SAM) via a folate-dependent enzyme which catalyses the production of S-adenosyl homocysteine (SAH), or by re-methylation of the next metabolite, homocysteine, via choline-betaine and vitamin B 12 -folate cycles that need ATP and are facilitated by ascorbic acid , the bioactive from of vitamin C (30)

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