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Absolute changes of body composition of 36-wk old male C57BL/6 J wildtype and Vgat-Gipr KO mice treated either with Vehicle (n = 8 WT and n = 8 KO), acyl-GLP-1 (n = 8 WT and n = 8 KO), or the co-therapy of acyl-GLP-1 and the GIPR antagonist (n = 8 WT and n = 7 KO) (g,h)
Both compounds work identically in male and female research modelsGH and ghrelin receptor physiology does not differ meaningfully by sex
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The compound incorporates N-terminal acetylation and C-terminal amidation , structural modifications commonly applied in peptide chemistry to influence molecular stability and resistance to enzymatic degradation in experimental systems
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