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Once released, GLP-1 acts on the pancreas to stimulate insulin secretion, inhibit glucagon, and slow gastric emptying

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By the end of the year-long study, those given Semaglutide injections lost on average 11.2-13.8% of their starting weight, whereas Liraglutide participants lost around 7-8%

Based on the populations studied in clinical trials to date, retatrutide has been investigated primarily in adults living with obesity defined as a body mass index (BMI) of 30 kg/m or above as well as in those who are overweight (BMI 27 kg/m or above) with at least one weight-related comorbidity, such as type 2 diabetes, hypertension, or dyslipidaemia