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FOXO4-DRIs D-retro-inverso configuration provides exceptional proteolytic stability compared to equivalent L-amino acid senolytic peptides a critical property for cell-based and pre-clinical research where intracellular peptidase activity would rapidly degrade unstable L-amino acid sequences

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The methylenetetrahydrofolate reductase (MTHFR) enzyme is essential for catalyzing the conversion of folic acid to the biologically active form, methylfolate