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The AUC was calculated with the following equations: AUC for serum insulin = (insulin 0min + insulin 30min ) 30/2 + (insulin 30min + insulin 120min ) 90/2 + (insulin 120min + insulin 180min ) 60/2, AUC for glucagon= (glucagon 0min + glucagon 30min ) 30/2 + (glucagon 30min + glucagon 120min ) 90/2 + (glucagon 120min + glucagon 180min ) 60/2 and AUC for plasma GLP-1 = (GLP-1 0min + GLP-1 30min ) 30/2 + (GLP-1 30min + GLP-1 120min ) 90/2 + (GLP-1 120min + GLP-1 180min ) 60/2

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Cell viability and Melanin quantification assay The inhibitory effect of T1 on human melanin formation was investigated

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