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To target E2 to -cells without the undesirable effects of general estrogen therapy, we created fusion peptides combining active or inactive glucagon-like peptide-1 (GLP-1) and E2 in a single molecule (aGLP1-E2 and iGLP1-E2 respectively)

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This regenerative effect can support the repair of damaged cartilage, ligaments, and tendons in the knee, leading to improved function and reduced pain