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The MSC-induced changes in signal factors also have the properties of reducing fibrosis and stimulating angiogenesis which can lead to improvements in vascular structure and function, primarily including VEGF, fibroblast growth factor 2 (FGF-2), PDGF, SDF-1, chemokine (C-X-C motif) ligand 1 (CXCL-1), RANTES, MCP-1, macrophagecolony stimulating factor (M-CSF) [88, 92, 94]

(2021) PLoS ONE | Yancey, P., Gerringer, M., Drazen, J.,et al.: Marine fish may be biochemically constrained from inhabiting the deepest ocean depths

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