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At issue is the GLP-1 receptor agonist, which helps lower blood sugar levels by promoting the excretion of insulin

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Persistence is key: Roughly 36%50% of patients discontinue within 12 months, affecting long-term cost projections

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For Reference A new study (PubMed ID: 38218536) looked at combining GLP-1 receptor agonists with ActRII inhibitors, a class of therapies that can block pathways linked to muscle breakdown

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Adding glucagon agonism (retatrutide) does not reproduce that protective effect

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