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52 Recently, studies on the transfer of glutamine in living cells using glutamine fluorescence probes have shown that glutamine can be released through astrocytic connexin (Cx) hemichannels (HM) to ensure neurotransmitter transmission and cognitive ability

As discussed earlier, PRDX6 binds GPX4 through a Cys47-mediated disulfide bond, facilitating GPX4 localization to cellular membranes and enhancing lipid peroxide detoxification 100

ROS, Reactive Oxygen Species

Some studies revealed that because of high concentration in plasma, UA can act as a pro-oxidant within the cell by scavenging and creating ROS or it can act as an antioxidant, which mainly occurs in plasma [122,123,124]