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These substances can: Increase insulin resistance Elevate inflammatory markers such as C-reactive protein (CRP) Disrupt hormone balance Promote oxidative stress As metabolic dysfunction worsens, inflammation increases, creating a cycle that can be difficult to reverse through lifestyle changes alone

Vitamin C increased glutathione levels by recycling used glutathione in one human study (DB-RCT) [50]

19 Gene expression differences involved in O-GlcNAcylation and hexosamine biosynthesis pathway have also been detected between diabetic and nondiabetic individuals, 20 probably because multiple molecules in insulin signaling pathways can be modified by glycosylation which in turn reduces phosphorylation, leading to inhibition of insulin signaling

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