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Cell cycle signaling pathways and oocyte meiosis signaling pathways play an important role in oocyte maturation [40, 41]

doi: 10.3389/fimmu.2023.1212476 178 AkinsipeTMohamedelhassanRAkinpeluAPondugulaSRMistriotisPAvilaLAet al

Building on these results, a phase 1b trial in individuals with T2D further evaluated the safety, pharmacokinetics, and pharmacodynamics of once-weekly retatrutide over 12 weeks [43]

In a multicenter, randomized, placebo-controlled dose-finding trial, cagrilintide at doses ranging from 0.3 to 4.5 mg weekly produced dose-dependent weight reductions, with the 4.5 mg dose achieving approximately 10.8% weight loss at 26 weeks compared to 3.0% with placebo