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For example, in a 3-week prospective intervention with a high dose of 100 mg riboflavin/day with 70 patients with Crohns Disease, a reduction in systemic oxidative stress (measured by higher free thiol plasma levels), inflammatory markers (IL-2 and C-reactive protein (CRP)) and clinical symptoms of Crohns disease (i.e., a reduction in clinical disease activity index and quality of life improvement) were observed 52