Titrating slowly helps the gastrointestinal system adapt to the delayed gastric emptying and appetite suppression effects
Patients should seek prompt medical guidance for severe or persistent vomiting, signs of dehydration, severe abdominal pain, fainting, symptoms of low blood sugar, inability to keep fluids down, worsening constipation with pain or bloating, or any symptom that feels unsafe
For GLP-1 medications, insurers may require evidence that the patient has tried other treatments or that the medication is essential for managing weight loss in the presence of other conditions like type 2 diabetes, hypertension, or cardiovascular disease
28,29 Although highly effective, 30 patients must administer injections of exenatide multiple times a day leading to low patient compliance