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We also used t-SNE to analyze the profile of motor effects induced by appetite suppressants, in this case, clustering rats exhibiting similar motor side effects

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Eur J Pharmacol 319:369373 Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, Macneil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, Mcgowan E, Cashen DE, Drisko JE, Hom GJ, Howard AD, Macintyre DE, Van Der Ploeg LH, Patchett AA, Nargund RP (2002) Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist