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Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc-/GPX4 pathway

Plants have evolved specific strategies too in order to neutralize potentially harmful compounds such as xenobiotics and heavy metals

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For instance, niclosamide functioning as a FSP-1 transcriptional inhibitor, demonstrated potential in reducing liver metastasis of colon cancer and boosting efficacy of ICIs in preclinical models [310, 311]