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617, 38 10.1016/j.abb.2016.09.012 [DOI] [PubMed] [Google Scholar] 61.Ida T., Sawa T., Ihara H., Tsuchiya Y., Watanabe Y., Kumagai Y.et al

Lyophilized (powder) DSIP should be stored in the freezer at -20C for maximum stability

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It suppresses IL-6 and TNF- production while enhancing IL-10 production in macrophages, and inhibits the mTOR/STAT3 pathway in T cells, thereby reducing proinflammatory Th17 cells and cytokines such as IL-17 and IL-22, while promoting regulatory T-cell (Treg) differentiation (21)