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Pre-protocol planning Before the first injection, establish these foundational elements: Define your research objectives

Temperature fluctuations degrade the peptide structure [12][15]

The opposing effects on blood glucose could create unpredictable glycaemic fluctuations, particularly in individuals with pre-existing diabetes or impaired glucose tolerance

What guidelines and real-world practice say Despite the lack of direct trials, major guidelines support: Using the lowest effective dose Shared decision-making Individualised plans In real-world practice, many clinicians: Use a maintenance phase Reduce dose gradually Monitor appetite, weight stability, and wellbeing Adjust based on how the person feels, not just the scales This approach is not because we have perfect data, but because it aligns with physiology, patient experience, and common sense