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Peden DL et al

Mudgal and coworkers demonstrated that in Swiss mice treated with LPS, a one-week treatment with a low dose of caffeine and a low dose of caffeic acid produced anxiolytic effects in the OFT and DLB, antidepressant effects in OFT and DLB, and anti-inflammatory effects with reduction of IL-6 and TNF-alpha in serum and brain [34]

Histopathological findings revealed preservation of neural architecture, with reduced axonal degeneration, diminished neuronal loss, and limited formation of cystic cavities, suggesting an attenuation of secondary injury processes (12)