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The HLCS gene is located on chromosome 21q22.13 and is composed of 19 exons that generate eight alternatively spliced mRNAs, seven of which encode the same 726 amino acid protein (isoform 1) and one which encodes a 873 amino acid protein (isoform 2)

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A study of BRICS (Brazil, Russia, India, China, and South Africa) countries during 2007-2010 found that obesity was associated with hypertension, angina, diabetes, and arthritis (5)

It is the latest step in a concerted push by the pharmaceutical industry to develop an oral treatment to rival the results of the GLP-1 injectable medications, which have surged in popularity