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This degradation is catalyzed by the ubiquitous serum enzyme dipeptidyl peptidase 4 (DPP-4), which is produced both locally in the intestine and by circulating white blood cells
Barnes notes the pill can be a great option for those transitioning to maintenance or hoping for a more flexible long-term treatment option. For some, taking a daily pill feels more sustainable than committing to weekly injections indefinitely
Short-acting GLP-1 RAs (e.g., exenatide, lixisenatide) were found to have a reduced impact on overnight and fasting blood glucose levels, while long-acting GLP-1 RAs (liraglutide, exenatide once weekly, dulaglutide, and semaglutide) were found to have an increased effect and better coverage on overnight and fasting blood glucose and HbA1c levels [18]
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