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Additionally, glutaminase (GLS), which metabolizes glutamine to glutamate, is a NRF2 target gene [74]

The PROMIS T -score metric is anchored to the United States general population, and a cutoff T -score of 50 differentiates clinically meaningful fatigue in the oncology population ( Metabolomics Untargeted metabolomics analysis was performed at Metabolon, Inc., (Durham, NC, United States), as previously described ( via negative ionization following elution from a HILIC column (Waters UPLC BEH Amide 2.1 150 mm, 1.7 m) using a gradient consisting of water and acetonitrile with 10 mM ammonium formate, pH 10.8

Ferroptosis can be induced by glutathione depletion Ferroptosis can be induced by depriving cells of the essential GSH precursor, Cys, or by blocking the function of the GSH-dependent enzyme GPX4 (see above)

Results: Se, SelP, and GPx levels of the hyperthyroidism group were lower than the control group