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PGC1 is the master regulator of mitochondrial biogenesis 34 , and we see a small but sustained increase in PGC1 expression in response to 5FU over 72 h treatment (Fig

Routine MS/MS analysis is performed on two instruments (API 4000 AB SCIEX, Toronto, Canada) and one additional instrument (API 2000 AB SCIEX) for back up

PMCID: PMC10667917