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Firstly, there is an urgent need for extended follow-up studies that last longer than current trial lengths to assess the long-term safety and efficacy of therapies over a decade or more

After the microneedle is inserted into the psoriatic skin, the needle tip separates from the base, and MTX is rapidly released from the swollen gel pores, promptly inhibiting keratinocyte proliferation, while EGCG breaks the bond in response to the high ROS environment in the skin and releases in an intelligent and controlled manner, effectively inhibiting the NF-B inflammatory pathway for a long time ( Although antioxidants have a strong ability to remove ROS, the poor stability and difficulty in penetrating the cell membrane limit their clinical development and application

doi:10.1074/jbc.M209064200