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Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil are often effective first-line treatments and are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrate medications and riociguat, and should be used with caution in unstable cardiovascular disease or if taking alpha-blockers

It says clinical trials show GLP-1 agonists lower HbA1c by 1 to 2 percent in diabetes settings and produce 5 to 15 percent body weight reduction in weight management studies