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A randomised placebo-controlled trial (RCT) including 42 participants with schizophrenia, who were experiencing an acute phase of symptomatology, were randomly assigned to receive up to 2 g/d of NAC plus up to 6 mg/d of risperidone for 8 weeks as an adjunct intervention
It does not create a branded finished drug, it does not trigger insurance coverage, and it does not retroactively validate marketing claims made about the compound
However, this acute oxidative stress serves as a hormetic stimulus that triggers adaptive responses, including upregulation of endogenous antioxidant systems including glutathione synthesis
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