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Appetite Regulation & Metabolic Effects MC3R and MC4R activation by MT-II is associated in research with appetite suppression and reduced food intake effects mediated through hypothalamic melanocortin signaling pathways

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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]