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That shift in timescale is not just a pharmacological footnote

We note that although the chondroprotective effects of metformin was clearly attenuated in Nrf2 KO mice, micro-CT analysis revealed some variability in trabecular bone parameters, including occasional increases in subchondral trabecular bone amounts in Nrf2 KO OA mice (Fig

Studies show that people on GLP-1 therapy lose an average of 15-22% of their body weight over 68 weeks, but that loss includes muscle unless you eat enough protein