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A few patient samples have also demonstrated thickening of the subependymal cell layer, heterotopias reflecting abnormal neuronal migration and multifocal cerebral and cerebellar dyplasias (162)

Patients with neurodegenerative diseases, post-COVID neurological fatigue, traumatic brain injury, or age-related neuroendocrine decline frequently experience treatment-resistant insomnia, indicating a need for therapeutic options that actively restore neurological integrity

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