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Severe diarrhea can lead to dehydration

The anti-androgen effect persists because spironolactone's active metabolite, canrenone, has a half-life of 13 to 24 hours, making once-daily morning dosing pharmacologically sufficient for hormonal indications

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Some people experience less nausea and cramping with oral semaglutide compared to injections because absorption is slower and more gradual, though both formulations work through the same GLP-1 pathway