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[DOI] [PMC free article] [PubMed] [Google Scholar] Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K

The fear factor is real

with its unique mechanism of action

Liraglutide injection into the VMH of mice induced weight loss and increased thermogenetic activity, as evidenced by elevated uncoupling protein 1 expression in both BAT and white adipose tissue, with adenosine monophosphate-activated protein kinase (AMPK) signaling in the VMH required as a mediator [71]