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Methods We searched MEDLINE (19962014), EMBase (19742014), and CENTRAL (May 2014) up to June 27, 2014 for randomized controlled trials (RCTs) comparing ALC with placebo or other active medications in diabetic and non-diabetic PNP patients that reported the change of pain using visual analogue scale (VAS)

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Additionally, to explore the therapeutic potential of ROS homeostasis modulation in disease treatment, this review comprehensively summarizes existing drugs and intervention strategies targeting ROS hemeostasis, while also exploring emerging therapeutic approaches