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Obesity Treatment is Being Explored Through the Development of Oral Medications that Function as GLP- 1 Receptor Agonists Semaglutide A randomized, double-blind, phase III study found that giving adults overweight or obese (without T2DM) 50 mg of oral semaglutide once daily for 68 weeks, in addition to diet and exercise, significantly reduced their body weight in comparison with a placebo (15% vs

Sci Total Environ 866:161458 Funding National Natural Science Foundation of China (82301924), Science and Technology Department of Sichuan Province (2023YFS0217)

Taking more than the recommended dose wont necessarily increase the benefits and could lead to unwanted side effects

For example, senescent cells upregulate BCL2 family proteins such as BCL-XL, BCL-W 24 or MCL-1 25 to prevent intrinsic apoptosis