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While ROS scavenging is beneficial in chronic diseases like diabetes (Zhang et al., 2020), excessive antioxidant supplementation may disrupt redox homeostasis, as evidenced by increased cancer risk in vitamin E trials ( Antioxidants, which include both enzymatic (e.g., SOD, CAT) and non-enzymatic agents (e.g., ALA, polyphenols), counteract ROS by restoring redox balance and modulating inflammatory and apoptotic pathways

Braak H, Braak E, Bohl J

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In cases where estrogen or progesterone are imbalanced, hormone replacement therapy (HRT) would be a more appropriate treatment option to address these concerns