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Following liver resection, elevated bile salts activate FXR and upregulate IL-6/STAT3/c-JUN signaling to promote regeneration
Sinclair is a co-founder of Sirtris, a company that itself has been swimming in uncharted waters as it works to develop drugs that may extend the human life span
Retatrutide dosage escalation (Phase 2 trial protocol) The Phase 2 trial tested multiple starting dose strategies
Biodegradable MPs such as PLA and Poly(-caprolactone) underwent degradation and oligomerization while significantly depleting beneficial bacteria including Bifidobacterium, Lactobacillus, Faecalibacterium, Blautia , and Ruminococcus (Peng et al., 2024)
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