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The improvements in their exercise endurance and heart function were in addition to the improvements already observed with two current treatments for heart failure, beta-blockers and ACE inhibitors

Researchers are particularly interested in its behavior under metabolic stress, where mitochondrial-derived peptides appear to play a regulatory role in how cells adapt energy production to changing demands

Thus, a significant amount of protein accumulates in the brain over many years before a sufficient amount of brain injury has occurred to cause symptoms noticed by the patient or family/friends

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