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L-arginine: safety, side effects and interactions
In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al
Accumulation of membrane-associated oxidized hemoglobin is considered to be one of the major (but not the only) trigger of band 3 cluster formation (Low et al., 1985
Metabolic regulation of cell growth and proliferation
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