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Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

A bias factor ( ), which quantifies the relative engagement of one signalling state over another compared with the reference peptide, was calculated using the following equation: Where E max is the maximal effect, EC 50 is the half maximal concentration of the peptide, lig is the peptide being tested (P5 or GLP-1)

Clinical trials reported that the intake of some nutraceuticals (Hawthorn, Coenzyme Q10, L-carnitine, D-ribose, Carnosine, Vitamin D, Probiotics, Omega-3 PUFAs, Beet nitrates) is associated with improvements in self-perceived quality of life and/or functional parameters such as ejection fraction, stroke volume and cardiac output in HF patients, with minimal or no side effects