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If it's still hanging around after that, or starts getting red or purple, hot or more painful, it's a good idea to check in with your doctor

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Anyone considering weight management treatment should consult their GP or a specialist obesity service in the first instance

In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy