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In this prespecified analysis of SELECT, we demonstrated CV benefits of semaglutide in people with overweight or obesity and established CVD, but without diabetes, are independent of baseline HbA1c and the magnitude of change in HbA1c, Ildiko Lingvay, MD, MPH, MSCS, professor of medicine at the University of Texas Southwestern Medical Center in Dallas, said during a presentation

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It is reported that GSH depletion in antigen presenting cells inhibits Th1-related cytokine production like IFN- and IL-12 and supports the Th2- mediated humoral immune response [80]

These cases collectively suggest a potential link between semaglutide use and the development or exacerbation of depressive symptoms, warranting closer monitoring in clinical practice