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The most common side effects include nausea, constipation, bloating, reduced appetite, fatigue, and mild headaches

Both share similar gastrointestinal side effects (nausea, diarrhea, vomiting, abdominal pain), but Trulicity has higher hypoglycemia risk when used with other diabetes medications

This triagonist mechanism is widely studied in metabolic and incretin-signaling research models, and in published clinical research has been associated with greater reductions than dual GLP-1/GIP agonists in comparable trials