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This combination also makes it harder for your liver to process both substances, potentially leading to higher toxicity

The brain is also a major site of Mn deposition, with regional concentrations ranging from 0.16 to 0.46 mg/kg, the highest levels found in the globus pallidus and putamen, regions primarily responsible for motor control (Krebs et al., 2014)

Genetic mutations that decrease WFS1 are linked to depression, psychiatric disorders, and suicide risk.[ref][ref][ref] This is just the tip of the iceberg in terms of genes that can impact mitochondrial function