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[DOI] [PubMed] [Google Scholar] DiMarchi R

1d , Supplementary Table 1), suggesting that GLP-1 receptor activation coordinates a broad program of inflammatory resolution rather than targeting individual inflammatory mediators Semaglutide dampens LPS-induced expression changes in glial cells and infiltration of peripheral neutrophils To map the cell type specific effects of LPS in combination with GLP-1 receptor activation, we performed single-nucleus RNA sequencing (snRNA-seq) of the hippocampus (n=71) spanning the acute (2h, 24h) and sub-chronic (5d, 11d) phases of inflammation ( Fig