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Cardiovascular effects, such as a rise in blood pressure and tachycardia, were usually mild, while the risk of seizure, which was high with the original bupropion formulation, has been significantly reduced with the advent of bupropion-SR and bupropion-ER

However, it is important to note that the vast majority of this data comes from animal models, and human clinical trial data remains limited

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PMID: 41476424