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Semaglutide In the SURMOUNT1 trial, adults with obesity but no diabetes lost about 16%, 21%, and 22.5% of their starting weight on tirzepatide 5 mg, 10 mg, and 15 mg once weekly, with average losses at the top dose around 52 pounds. In the STEP 1 trial semaglutide obesity trials, onceweekly semaglutide 2.4 mg produced roughly 15% average weight loss at 68 weeks, far outperforming placebo and older agents. A 2025 metaanalysis pooling randomized trials and realworld cohorts found tirzepatide produced about 4 percentage points more weight loss than semaglutide overall , with a clear doseresponse when tirzepatide doses exceeded 10 mg. Recent headtohead and cohort work in adults with overweight or obesity confirms this pattern: tirzepatide is consistently superior for absolute weight and waistcircumference reduction at roughly 72 weeks. What do those percentages mean in real life